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Splenectomy increases the survival time of heart allograft via developing immune tolerance

BACKGROUND: The spleen is an active lymphoid organ. The effect of splenectomy on the immune response remains unclear. This study investigated whether splenectomy can induce immune tolerance and has a beneficial role in cardiac allograft. METHODS: Wistar rats were used for heart donors. The Sprague–D...

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Detalles Bibliográficos
Autores principales: Zhu, Jinguo, Chen, Shuzhen, Wang, Jinju, Zhang, Cheng, Zhang, Wei, Liu, Peng, Ma, Ruilian, Chen, Yanfang, Yao, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667018/
https://www.ncbi.nlm.nih.gov/pubmed/23680475
http://dx.doi.org/10.1186/1749-8090-8-129