Colon cancer cells adopt an invasive phenotype without mesenchymal transition in 3-D but not 2-D culture upon combined stimulation with EGF and crypt growth factors

BACKGROUND: The intestinal crypt homeostasis is maintained by a combination of growth factors including Wnt, R-Spondin1, Noggin and the epidermal growth factor (EGF). In human colorectal cancer, the Wnt pathway is constitutively activated through genetic and epigenetic alterations in as many as 11 g...

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Detalles Bibliográficos
Autores principales: Ludwig, Kirsten, Tse, Edison S, Wang, Jean YJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667045/
https://www.ncbi.nlm.nih.gov/pubmed/23638973
http://dx.doi.org/10.1186/1471-2407-13-221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667045/
https://www.ncbi.nlm.nih.gov/pubmed/23638973
http://dx.doi.org/10.1186/1471-2407-13-221

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