Characterization of a Tumor-Associated Activating Mutation of the p110β PI 3-Kinase

The PI3-kinase pathway is commonly activated in tumors, most often by loss of PTEN lipid phosphatase activity or the amplification or mutation of p110α. Oncogenic mutants have commonly been found in p110α, but rarely in any of the other catalytic subunits of class I PI3-kinases. We here characterize...

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Detalles Bibliográficos
Autores principales: Dbouk, Hashem A., Khalil, Bassem D., Wu, Haiyan, Shymanets, Aliaksei, Nürnberg, Bernd, Backer, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667187/
https://www.ncbi.nlm.nih.gov/pubmed/23734178
http://dx.doi.org/10.1371/journal.pone.0063833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667187/
https://www.ncbi.nlm.nih.gov/pubmed/23734178
http://dx.doi.org/10.1371/journal.pone.0063833

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