TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells

Mucin 5AC (MUC5AC) is secreted by goblet cells of the respiratory tract and, surprisingly, also expressed de novo in mucus secreting cancer lines. siRNA-mediated knockdown of 7343 human gene products in a human colonic cancer goblet cell line (HT29-18N2) revealed new proteins, including a Ca(2+)-act...

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Detalles Bibliográficos
Autores principales: Mitrovic, Sandra, Nogueira, Cristina, Cantero-Recasens, Gerard, Kiefer, Kerstin, Fernández-Fernández, José M, Popoff, Jean-François, Casano, Laetitia, Bard, Frederic A, Gomez, Raul, Valverde, Miguel A, Malhotra, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667631/
https://www.ncbi.nlm.nih.gov/pubmed/23741618
http://dx.doi.org/10.7554/eLife.00658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667631/
https://www.ncbi.nlm.nih.gov/pubmed/23741618
http://dx.doi.org/10.7554/eLife.00658

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