Cargando…

TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells

Mucin 5AC (MUC5AC) is secreted by goblet cells of the respiratory tract and, surprisingly, also expressed de novo in mucus secreting cancer lines. siRNA-mediated knockdown of 7343 human gene products in a human colonic cancer goblet cell line (HT29-18N2) revealed new proteins, including a Ca(2+)-act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mitrovic, Sandra, Nogueira, Cristina, Cantero-Recasens, Gerard, Kiefer, Kerstin, Fernández-Fernández, José M, Popoff, Jean-François, Casano, Laetitia, Bard, Frederic A, Gomez, Raul, Valverde, Miguel A, Malhotra, Vivek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2013
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667631/ https://www.ncbi.nlm.nih.gov/pubmed/23741618 http://dx.doi.org/10.7554/eLife.00658

Ejemplares similares

Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion
por: Cantero-Recasens, Gerard, et al.
Publicado: (2022)

KChIP3 coupled to Ca(2+) oscillations exerts a tonic brake on baseline mucin release in the colon
por: Cantero-Recasens, Gerard, et al.
Publicado: (2018)

The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins
por: Cantero-Recasens, Gerard, et al.
Publicado: (2022)

The protective role of conjunctival goblet cell mucin sialylation
por: Matsuzawa, Moe, et al.
Publicado: (2023)

Zinc Deficiency Disturbs Mucin Expression, O-Glycosylation and Secretion by Intestinal Goblet Cells
por: Maares, Maria, et al.
Publicado: (2020)

Proteomic Study of the Mucin Granulae in an Intestinal Goblet Cell Model
por: Rodríguez-Piñeiro, Ana M., et al.
Publicado: (2012)

Goblet Cells and Mucins: Role in Innate Defense in Enteric Infections
por: Kim, Janice J., et al.
Publicado: (2013)

Activation of the EGF Receptor by Histamine Receptor Subtypes Stimulates Mucin Secretion in Conjunctival Goblet Cells
por: He, Min, et al.
Publicado: (2018)

Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress
por: Kim, Young S., et al.
Publicado: (2010)

Baseline Goblet Cell Mucin Secretion in the Airways Exceeds Stimulated Secretion over Extended Time Periods, and Is Sensitive to Shear Stress and Intracellular Mucin Stores
por: Zhu, Yunxiang, et al.
Publicado: (2015)

Goblet Cells and Mucin Related Gene Expression in Mice Infected with Eimeria papillata
por: Dkhil, Mohamed A., et al.
Publicado: (2013)

Goblet Cell Hyperplasia Requires High Bicarbonate Transport To Support Mucin Release
por: Gorrieri, Giulia, et al.
Publicado: (2016)

Inhibition of microRNA-328 Increases Ocular Mucin Expression and Conjunctival Goblet Cells
por: Choo, Jackson, et al.
Publicado: (2023)

Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways
por: Lippestad, Marit, et al.
Publicado: (2017)

Mucin granule-associated proteins in human bronchial epithelial cells: the airway goblet cell "granulome"
por: Raiford, Kimberly L, et al.
Publicado: (2011)

The monoclonal antibody HCM31 specifically recognises the Sd(a) tetrasaccharide in goblet cell mucin
por: Tsubokawa, Daigo, et al.
Publicado: (2012)

Characterization of mucin gene expression and goblet cell proportion in inflammatory colorectal polyps in miniature dachshunds
por: NAGATA, Noriyuki, et al.
Publicado: (2022)

Effects of mycophenolate mofetil on proliferation and mucin-5AC expression in human conjunctival goblet cells in vitro
por: He, Hong, et al.
Publicado: (2010)

Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall
por: Gupta, Anuja, et al.
Publicado: (2013)

Metformin Improves Cognition by Reducing Leaky Gut and Benefiting Gut Microbiome–Goblet Cell–Mucin Axis
por: Yadav, Hariom, et al.
Publicado: (2020)

The morphological changes of the colonic goblet cells and mucin profile in oncohematological patients under Epirubicin-based chemotherapy
por: Cotoraci, Coralia Adina, et al.
Publicado: (2020)

Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins
por: Johansson, Malin E. V.
Publicado: (2012)

A198 COLONIC MUC2 MUCIN IS STABILIZED BY FCGBP TO RESIST SALMONELLA TYPHIMURIUM INVASION IN GOBLET CELLS
por: Gorman, H, et al.
Publicado: (2022)

Secretion of endogenous lectin by chicken intestinal goblet cells
Publicado: (1982)

Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis
por: Gustafsson, Jenny K, et al.
Publicado: (2021)

Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell
por: D'Elia, Riccardo, et al.
Publicado: (2009)

Resolvin D1 Treatment on Goblet Cell Mucin and Immune Responses in the Chronic Allergic Eye Disease (AED) Model
por: Saban, Daniel R., et al.
Publicado: (2018)

VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
por: Cornick, Steve, et al.
Publicado: (2019)

Mechanism of rapid mucus secretion in goblet cells stimulated by acetylcholine
Publicado: (1980)

The Regulated Secretion and Models of Intracellular Transport: The Goblet Cell as an Example
por: Mironov, Alexander A., et al.
Publicado: (2023)

Novel Dent disease 1 cellular models reveal biological processes underlying ClC-5 loss-of-function
por: Durán, Mónica, et al.
Publicado: (2021)

Thyroid hormones increase stomach goblet cell numbers and mucin expression during indomethacin induced ulcer healing in Wistar rats
por: Namulema, Jackline, et al.
Publicado: (2018)

Harry Potter and the goblet of fire /
por: Rowling, J. K.
Publicado: (2000)

Goblet Cell Carcinoids of the Appendix
por: Arnold, R, et al.
Publicado: (2006)

Goblet cell carcinoid of the appendix
por: Pahlavan, Payam S, et al.
Publicado: (2005)

Goblet Cell Carcinoids of the Appendix
por: Holt, Nanna, et al.
Publicado: (2013)

TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon
por: Luongo, Francesca, et al.
Publicado: (2018)

Pro-Resolving Mediator Annexin A1 Regulates Intracellular Ca(2+) and Mucin Secretion in Cultured Goblet Cells Suggesting a New Use in Inflammatory Conjunctival Diseases
por: Lyngstadaas, Anne V., et al.
Publicado: (2021)

Entamoeba histolytica Cysteine Proteinase 5 Evokes Mucin Exocytosis from Colonic Goblet Cells via αvβ3 Integrin
por: Cornick, Steve, et al.
Publicado: (2016)

Internal biliary drainage superior to external biliary drainage in improving gut mucosa barrier because of goblet cells and mucin-2 up-regulation
por: Tang, Xuechan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mb3o36lvbs0ii2npdomb9e89mt