Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein–coupled receptor kinase–dependent manner

Most α-synuclein (α-syn) deposited in Lewy bodies, the pathological hallmark of Parkinson disease (PD), is phosphorylated at Ser-129. However, the physiological and pathological roles of this modification are unclear. Here we investigate the effects of Ser-129 phosphorylation on dopamine (DA) uptake...

Descripción completa

Detalles Bibliográficos
Autores principales: Hara, Susumu, Arawaka, Shigeki, Sato, Hiroyasu, Machiya, Youhei, Cui, Can, Sasaki, Asuka, Koyama, Shingo, Kato, Takeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667719/
https://www.ncbi.nlm.nih.gov/pubmed/23576548
http://dx.doi.org/10.1091/mbc.E12-12-0903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667719/
https://www.ncbi.nlm.nih.gov/pubmed/23576548
http://dx.doi.org/10.1091/mbc.E12-12-0903

Ejemplares similares