Extracellular Domains of CD8α and CD8ß Subunits Are Sufficient for HLA Class I Restricted Helper Functions of TCR-Engineered CD4(+) T Cells

By gene transfer of HLA-class I restricted T-cell receptors (TCRs) (HLA-I-TCR) into CD8(+) as well as CD4(+) T-cells, both effector T-cells as well as helper T-cells can be generated. Since most HLA-I-TCRs function best in the presence of the CD8 co-receptor, the CD8αß molecule has to be co-transfer...

Descripción completa

Detalles Bibliográficos
Autores principales: van Loenen, Marleen M., Hagedoorn, Renate S., de Boer, Renate, Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667802/
https://www.ncbi.nlm.nih.gov/pubmed/23738014
http://dx.doi.org/10.1371/journal.pone.0065212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667802/
https://www.ncbi.nlm.nih.gov/pubmed/23738014
http://dx.doi.org/10.1371/journal.pone.0065212

Ejemplares similares