Biological Networks for Predicting Chemical Hepatocarcinogenicity Using Gene Expression Data from Treated Mice and Relevance across Human and Rat Species

BACKGROUND: Several groups have employed genomic data from subchronic chemical toxicity studies in rodents (90 days) to derive gene-centric predictors of chronic toxicity and carcinogenicity. Genes are annotated to belong to biological processes or molecular pathways that are mechanistically well un...

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Detalles Bibliográficos
Autores principales: Thomas, Reuben, Thomas, Russell S., Auerbach, Scott S., Portier, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667849/
https://www.ncbi.nlm.nih.gov/pubmed/23737943
http://dx.doi.org/10.1371/journal.pone.0063308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667849/
https://www.ncbi.nlm.nih.gov/pubmed/23737943
http://dx.doi.org/10.1371/journal.pone.0063308

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