Plasmacytoid dendritic cells and regulatory T cells in the tumor microenvironment: A dangerous liaison

Tumor-infiltrating plasmacytoid dendritic cells (pDCs) have been associated with poor patient prognosis. We have recently uncovered the ability of pDCs to activate and expand a subset of tumor-infiltrating FOXP3(+) regulatory T cells that express inducible costimulator (ICOS), providing new insights...

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Detalles Bibliográficos
Autores principales: Conrad, Curdin, Gilliet, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667894/
https://www.ncbi.nlm.nih.gov/pubmed/23762788
http://dx.doi.org/10.4161/onci.23887
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author Conrad, Curdin
Gilliet, Michel
author_facet Conrad, Curdin
Gilliet, Michel
author_sort Conrad, Curdin
collection PubMed
description Tumor-infiltrating plasmacytoid dendritic cells (pDCs) have been associated with poor patient prognosis. We have recently uncovered the ability of pDCs to activate and expand a subset of tumor-infiltrating FOXP3(+) regulatory T cells that express inducible costimulator (ICOS), providing new insights into the mechanisms that govern the escape of cancer from immunosurveillance.
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spelling pubmed-36678942013-06-12 Plasmacytoid dendritic cells and regulatory T cells in the tumor microenvironment: A dangerous liaison Conrad, Curdin Gilliet, Michel Oncoimmunology Author's View Tumor-infiltrating plasmacytoid dendritic cells (pDCs) have been associated with poor patient prognosis. We have recently uncovered the ability of pDCs to activate and expand a subset of tumor-infiltrating FOXP3(+) regulatory T cells that express inducible costimulator (ICOS), providing new insights into the mechanisms that govern the escape of cancer from immunosurveillance. Landes Bioscience 2013-05-01 2013-05-01 /pmc/articles/PMC3667894/ /pubmed/23762788 http://dx.doi.org/10.4161/onci.23887 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Conrad, Curdin
Gilliet, Michel
Plasmacytoid dendritic cells and regulatory T cells in the tumor microenvironment: A dangerous liaison
title Plasmacytoid dendritic cells and regulatory T cells in the tumor microenvironment: A dangerous liaison
title_full Plasmacytoid dendritic cells and regulatory T cells in the tumor microenvironment: A dangerous liaison
title_fullStr Plasmacytoid dendritic cells and regulatory T cells in the tumor microenvironment: A dangerous liaison
title_full_unstemmed Plasmacytoid dendritic cells and regulatory T cells in the tumor microenvironment: A dangerous liaison
title_short Plasmacytoid dendritic cells and regulatory T cells in the tumor microenvironment: A dangerous liaison
title_sort plasmacytoid dendritic cells and regulatory t cells in the tumor microenvironment: a dangerous liaison
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667894/
https://www.ncbi.nlm.nih.gov/pubmed/23762788
http://dx.doi.org/10.4161/onci.23887
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