A Janus-faced role of the unfolded protein response in antitumor immunity

The unfolded protein response (UPR) has been established as a cell-intrinsic mechanism of survival for malignant cells facing microenvironmental stressors. Recent evidence indicates that the UPR also modulates antitumor immunity. Here, we discuss the bi-faced role of the UPR as it both promotes and...

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Autores principales: Mahadevan, Navin R., Rodvold, Jeffrey J., Zanetti, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667895/
https://www.ncbi.nlm.nih.gov/pubmed/23762789
http://dx.doi.org/10.4161/onci.23901
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author Mahadevan, Navin R.
Rodvold, Jeffrey J.
Zanetti, Maurizio
author_facet Mahadevan, Navin R.
Rodvold, Jeffrey J.
Zanetti, Maurizio
author_sort Mahadevan, Navin R.
collection PubMed
description The unfolded protein response (UPR) has been established as a cell-intrinsic mechanism of survival for malignant cells facing microenvironmental stressors. Recent evidence indicates that the UPR also modulates antitumor immunity. Here, we discuss the bi-faced role of the UPR as it both promotes and antagonizes antitumor T-cell immunity.
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spelling pubmed-36678952013-06-12 A Janus-faced role of the unfolded protein response in antitumor immunity Mahadevan, Navin R. Rodvold, Jeffrey J. Zanetti, Maurizio Oncoimmunology Author's View The unfolded protein response (UPR) has been established as a cell-intrinsic mechanism of survival for malignant cells facing microenvironmental stressors. Recent evidence indicates that the UPR also modulates antitumor immunity. Here, we discuss the bi-faced role of the UPR as it both promotes and antagonizes antitumor T-cell immunity. Landes Bioscience 2013-05-01 2013-05-01 /pmc/articles/PMC3667895/ /pubmed/23762789 http://dx.doi.org/10.4161/onci.23901 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Mahadevan, Navin R.
Rodvold, Jeffrey J.
Zanetti, Maurizio
A Janus-faced role of the unfolded protein response in antitumor immunity
title A Janus-faced role of the unfolded protein response in antitumor immunity
title_full A Janus-faced role of the unfolded protein response in antitumor immunity
title_fullStr A Janus-faced role of the unfolded protein response in antitumor immunity
title_full_unstemmed A Janus-faced role of the unfolded protein response in antitumor immunity
title_short A Janus-faced role of the unfolded protein response in antitumor immunity
title_sort janus-faced role of the unfolded protein response in antitumor immunity
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667895/
https://www.ncbi.nlm.nih.gov/pubmed/23762789
http://dx.doi.org/10.4161/onci.23901
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