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Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFβ and activating RIG-I
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor that is activated by 5′-triphosphate RNA molecules to induce type I interferon secretion and apoptosis in response to viral infection. We have designed a bifunctional small-interfering RNA that combines transforming growth fact...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667904/ https://www.ncbi.nlm.nih.gov/pubmed/23762798 http://dx.doi.org/10.4161/onci.24170 |