Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFβ and activating RIG-I

Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor that is activated by 5′-triphosphate RNA molecules to induce type I interferon secretion and apoptosis in response to viral infection. We have designed a bifunctional small-interfering RNA that combines transforming growth fact...

Descripción completa

Detalles Bibliográficos
Autores principales: Schnurr, Max, Duewell, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667904/
https://www.ncbi.nlm.nih.gov/pubmed/23762798
http://dx.doi.org/10.4161/onci.24170
_version_ 1782271553480687616
author Schnurr, Max
Duewell, Peter
author_facet Schnurr, Max
Duewell, Peter
author_sort Schnurr, Max
collection PubMed
description Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor that is activated by 5′-triphosphate RNA molecules to induce type I interferon secretion and apoptosis in response to viral infection. We have designed a bifunctional small-interfering RNA that combines transforming growth factor β silencing with RIG-I activation to break tumor-induced immunosuppression. This strategy showed therapeutic efficacy in a murine model of pancreatic cancer.
format Online
Article
Text
id pubmed-3667904
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-36679042013-06-12 Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFβ and activating RIG-I Schnurr, Max Duewell, Peter Oncoimmunology Author's View Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor that is activated by 5′-triphosphate RNA molecules to induce type I interferon secretion and apoptosis in response to viral infection. We have designed a bifunctional small-interfering RNA that combines transforming growth factor β silencing with RIG-I activation to break tumor-induced immunosuppression. This strategy showed therapeutic efficacy in a murine model of pancreatic cancer. Landes Bioscience 2013-05-01 2013-05-01 /pmc/articles/PMC3667904/ /pubmed/23762798 http://dx.doi.org/10.4161/onci.24170 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Schnurr, Max
Duewell, Peter
Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFβ and activating RIG-I
title Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFβ and activating RIG-I
title_full Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFβ and activating RIG-I
title_fullStr Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFβ and activating RIG-I
title_full_unstemmed Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFβ and activating RIG-I
title_short Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFβ and activating RIG-I
title_sort breaking tumor-induced immunosuppression with 5′-triphosphate sirna silencing tgfβ and activating rig-i
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667904/
https://www.ncbi.nlm.nih.gov/pubmed/23762798
http://dx.doi.org/10.4161/onci.24170
work_keys_str_mv AT schnurrmax breakingtumorinducedimmunosuppressionwith5triphosphatesirnasilencingtgfbandactivatingrigi
AT duewellpeter breakingtumorinducedimmunosuppressionwith5triphosphatesirnasilencingtgfbandactivatingrigi

Ejemplares similares