Cargando…

Development of a robust cell-based high-throughput screening assay to identify targets of HIV-1 viral protein R dimerization

Targeting protein–protein interactions (PPI) is an emerging field in drug discovery. Dimerization and PPI are essential properties of human immunodeficiency virus (HIV)-1 proteins, their mediated functions, and virus biology. Additionally, dimerization is required for the functional interaction of H...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zych, Courtney, Domling, Alexander, Ayyavoo, Velpandi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668091/ https://www.ncbi.nlm.nih.gov/pubmed/23737660 http://dx.doi.org/10.2147/DDDT.S44139

Ejemplares similares

Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1)
por: Gupta, Ankit, et al.
Publicado: (2011)

Retraction: Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1)
por: Gupta, Ankit, et al.
Publicado: (2012)

Temporal transcriptional response to latency reversing agents identifies specific factors regulating HIV-1 viral transcriptional switch
por: Venkatachari, Narasimhan J., et al.
Publicado: (2015)

Innate Immune Evasion Strategies by Human Immunodeficiency Virus Type 1
por: Guha, Debjani, et al.
Publicado: (2013)

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysregulates neurogranin and induces synaptodendritic injury
por: Guha, Debjani, et al.
Publicado: (2018)

HIV-1 Infection of DC: Evidence for the Acquisition of Virus Particles from Infected T Cells by Antigen Uptake Mechanism
por: Venkatachari, Narasimhan J., et al.
Publicado: (2009)

Neuronal apoptosis by HIV-1 Vpr: contribution of proinflammatory molecular networks from infected target cells
por: Guha, Debjani, et al.
Publicado: (2012)

Reconstructing the temporal progression of HIV-1 immune response pathways
por: Jain, Siddhartha, et al.
Publicado: (2016)

Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia
por: dos Reis, Roberta S., et al.
Publicado: (2020)

High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites
por: Brown, Evan C., et al.
Publicado: (2023)

MicroRNA regulation and its effects on cellular transcriptome in Human Immunodeficiency Virus-1 (HIV-1) infected individuals with distinct viral load and CD4 cell counts
por: Duskova, Karolina, et al.
Publicado: (2013)

A robust bacterial assay for high-throughput screening of human 4-hydroxyphenylpyruvate dioxygenase inhibitors
por: Neuckermans, Jessie, et al.
Publicado: (2019)

A high-throughput screening assay to identify inhibitory antibodies targeting alphavirus release
por: Ramjag, Anushka, et al.
Publicado: (2022)

Synthesis of Tunable Fluorescent Imidazole-Fused Heterocycle Dimers
por: Zheng, Qiang, et al.
Publicado: (2022)

Big Data in Chemical Toxicity Research: The Use of High-Throughput Screening Assays To Identify Potential Toxicants
por: Zhu, Hao, et al.
Publicado: (2014)

Using in Vitro High Throughput Screening Assays to Identify Potential Endocrine-Disrupting Chemicals
por: Rotroff, Daniel M., et al.
Publicado: (2012)

Stress-Based High-Throughput Screening Assays to Identify Inhibitors of Cell Envelope Biogenesis
por: Steenhuis, Maurice, et al.
Publicado: (2020)

A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: Potential impact on CTL epitopes
por: Srinivasan, Alagarsamy, et al.
Publicado: (2008)

A Sensitive and Robust High-Throughput Screening Assay for Inhibitors of the Chikungunya Virus nsP1 Capping Enzyme
por: Bullard-Feibelman, Kristen M., et al.
Publicado: (2016)

A robust high-throughput fluorescent polarization assay for the evaluation and screening of SARS-CoV-2 fusion inhibitors
por: Yin, Xinjian, et al.
Publicado: (2021)

Nanoscale, automated, high throughput synthesis and screening for the accelerated discovery of protein modifiers
por: Gao, Kai, et al.
Publicado: (2021)

A novel assay for screening inhibitors targeting HIV-1 integrase dimerization based on Ni-NTA magnetic agarose beads
por: Zhang, Dawei, et al.
Publicado: (2016)

Integration of a miniaturized DMMB assay with high-throughput screening for identifying regulators of proteoglycan metabolism
por: Sun, Yi, et al.
Publicado: (2022)

Robust high-throughput assays to assess discrete steps in ubiquitination and related cascades
por: Fenteany, Gabriel, et al.
Publicado: (2020)

Comparison of the PATHFAST D-dimer assay with two POC D-dimer assays
por: Spanuth, E, et al.
Publicado: (2015)

High-Throughput Screening to Predict Chemical-Assay Interference
por: Borrel, Alexandre, et al.
Publicado: (2020)

Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay
por: Shaneyfelt, Mark E, et al.
Publicado: (2006)

A Unique Dual-Readout High-Throughput Screening Assay To Identify Antifungal Compounds with Aspergillus fumigatus
por: Beattie, Sarah R., et al.
Publicado: (2021)

A robust photoluminescence screening assay identifies uracil-DNA glycosylase inhibitors against prostate cancer
por: Li, Guodong, et al.
Publicado: (2020)

Protocol for high-throughput screening of SARS-CoV-2 main protease inhibitors using a robust fluorescence polarization assay
por: Zhang, Jing, et al.
Publicado: (2022)

A robust high-throughput fluorescence polarization assay for rapid screening of SARS-CoV-2 papain-like protease inhibitors
por: Yan, Haohao, et al.
Publicado: (2022)

Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery
por: Chiu, Winston, et al.
Publicado: (2023)

High-throughput chromatin screens to identify targets of senescence and aging
por: Sen, Payel
Publicado: (2020)

An Assay Suitable for High Throughput Screening of Anti-Influenza Drugs
por: Mao, Lili, et al.
Publicado: (2013)

Identification of Compounds That Interfere with High‐Throughput Screening Assay Technologies
por: David, Laurianne, et al.
Publicado: (2019)

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway
por: Klein, Wolfgang, et al.
Publicado: (2018)

A High-Throughput Screening Identifies MICU1 Targeting Compounds
por: Di Marco, Giulia, et al.
Publicado: (2020)

A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases
por: Samrat, Subodh Kumar, et al.
Publicado: (2023)

Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs)
por: Heap, Rachel E., et al.
Publicado: (2017)

Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds
por: Deng, Zhuo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_j9jihd4tlj4n4q4jrhcjjnku04