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In vivo and in silico analysis of PCNA ubiquitylation in the activation of the Post Replication Repair pathway in S. cerevisiae

BACKGROUND: The genome of living organisms is constantly exposed to several damaging agents that induce different types of DNA lesions, leading to cellular malfunctioning and onset of many diseases. To maintain genome stability, cells developed various repair and tolerance systems to counteract the...

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Detalles Bibliográficos
Autores principales: Amara, Flavio, Colombo, Riccardo, Cazzaniga, Paolo, Pescini, Dario, Csikász-Nagy, Attila, Falconi, Marco Muzi, Besozzi, Daniela, Plevani, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668150/
https://www.ncbi.nlm.nih.gov/pubmed/23514624
http://dx.doi.org/10.1186/1752-0509-7-24