Effect of Normalization on Statistical and Biological Interpretation of Gene Expression Profiles

An under-appreciated aspect of the genetic analysis of gene expression is the impact of post-probe level normalization on biological inference. Here we contrast nine different methods for normalization of an Illumina bead-array gene expression profiling dataset consisting of peripheral blood samples...

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Detalles Bibliográficos
Autores principales: Qin, Shaopu, Kim, Jinhee, Arafat, Dalia, Gibson, Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668151/
https://www.ncbi.nlm.nih.gov/pubmed/23755061
http://dx.doi.org/10.3389/fgene.2012.00160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668151/
https://www.ncbi.nlm.nih.gov/pubmed/23755061
http://dx.doi.org/10.3389/fgene.2012.00160

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