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Homology modeling and virtual screening approaches to identify potent inhibitors of VEB-1 β-lactamase

BACKGROUND: bla(VEB-1) is an integron-located extended-spectrum β-lactamase gene initially detected in Escherichia coli and Pseudomonas aeruginosa strains from south-east Asia. Several recent studies have reported that VEB-1-positive strains are highly resistant to ceftazidime, cefotaxime and aztreo...

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Detalles Bibliográficos
Autores principales: Messaoudi, Abdelmonaem, Belguith, Hatem, Ben Hamida, Jeannette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668210/
https://www.ncbi.nlm.nih.gov/pubmed/23547944
http://dx.doi.org/10.1186/1742-4682-10-22