Cargando…

Homology modeling and virtual screening approaches to identify potent inhibitors of VEB-1 β-lactamase

BACKGROUND: bla(VEB-1) is an integron-located extended-spectrum β-lactamase gene initially detected in Escherichia coli and Pseudomonas aeruginosa strains from south-east Asia. Several recent studies have reported that VEB-1-positive strains are highly resistant to ceftazidime, cefotaxime and aztreo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Messaoudi, Abdelmonaem, Belguith, Hatem, Ben Hamida, Jeannette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668210/ https://www.ncbi.nlm.nih.gov/pubmed/23547944 http://dx.doi.org/10.1186/1742-4682-10-22

Ejemplares similares

Three-Dimensional Structure of Arabidopsis thaliana Lipase Predicted by Homology Modeling Method
por: Messaoudi, Abdelmonaem, et al.
Publicado: (2011)

VEB-1 Extended-Spectrum β-lactamase–producing Acinetobacter baumannii, France
por: Naas, Thierry, et al.
Publicado: (2006)

Integrase-Mediated Recombination of the veb1 Gene Cassette Encoding an Extended-Spectrum β-Lactamase
por: Aubert, Daniel, et al.
Publicado: (2012)

VEB-1-like extended-spectrum beta-lactamases in Pseudomonas aeruginosa, Kuwait.
por: Poirel, L, et al.
Publicado: (2001)

Frequency of PER, VEB, SHV, TEM and CTX-M Genes in Resistant Strains of Pseudomonas aeruginosa Producing Extended Spectrum β-Lactamases
por: Bokaeian, Mohmmad, et al.
Publicado: (2014)

An Update on the Status of Potent Inhibitors of Metallo-β-Lactamases
por: Faridoon,, et al.
Publicado: (2013)

Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases
por: Spyrakis, Francesca, et al.
Publicado: (2020)

Resistance to ceftazidime-avibactam in a KPC-2–producing Klebsiella pneumoniae caused by the extended-spectrum beta-lactamase VEB-25
por: Findlay, Jacqueline, et al.
Publicado: (2023)

Discovery of Novel New Delhi Metallo-β-Lactamases-1 Inhibitors by Multistep Virtual Screening
por: Wang, Xuequan, et al.
Publicado: (2015)

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors
por: Li, Guo-Bo, et al.
Publicado: (2017)

Identification of Disalicyloyl Curcumin as a Potential DNA Polymerase Inhibitor for Marek’s Disease Herpesvirus: A Computational Study Using Virtual Screening and Molecular Dynamics Simulations
por: Cherif, Aziza, et al.
Publicado: (2023)

Homology Modeling and Virtual Screening to Discover Potent Inhibitors Targeting the Imidazole Glycerophosphate Dehydratase Protein in Staphylococcus xylosus
por: Chen, Xing-Ru, et al.
Publicado: (2017)

VEB-1 extended-spectrum β-lactamase-producing multidrug-resistant Proteus mirabilis sepsis outbreak in a neonatal intensive care unit in India: clinical and diagnostic implications
por: Jain, Sarika, et al.
Publicado: (2016)

Presence of bla(PER-1) and bla(VEB-1) beta-lactamase genes among isolates of Pseudomonas aeruginosa from South West of Iran
por: Davodian, Elham, et al.
Publicado: (2016)

Detection in two hospitals of transferable ceftazidime-avibactam resistance in Klebsiella pneumoniae due to a novel VEB β-lactamase variant with a Lys234Arg substitution, Greece, 2019
por: Voulgari, E., et al.
Publicado: (2020)

Computer aided screening of potent inhibitor compounds against inhibitor resistant TEM β-lactamase mutants from traditional Chinese medicine
por: Zhu, Qifeng, et al.
Publicado: (2014)

VEB-1 in Achromobacter xylosoxidans from Cystic Fibrosis Patient, France
por: Neuwirth, Catherine, et al.
Publicado: (2006)

Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019
por: Galani, Irene, et al.
Publicado: (2020)

Halogen-Substituted Triazolethioacetamides as a Potent Skeleton for the Development of Metallo-β-Lactamase Inhibitors
por: Zhang, Yilin, et al.
Publicado: (2019)

Discovery of the Novel Inhibitor Against New Delhi Metallo-β-Lactamase Based on Virtual Screening and Molecular Modelling
por: Wang, Xiyan, et al.
Publicado: (2020)

Closed Genome Sequence of an Environmental Aeromonas veronii Strain from California, United States, with an IncA/C Plasmid Carrying an Extended-Spectrum β-Lactamase Gene, bla(VEB-3)
por: Lovero, Karissa G., et al.
Publicado: (2022)

β-Lactamases and β-Lactamase Inhibitors in the 21st Century
por: Tooke, Catherine L., et al.
Publicado: (2019)

β-lactamases (bla (TEM), bla (SHV), bla (CTXM-1), bla (VEB), bla (OXA-1)) and class C β-lactamases gene frequency in Pseudomonas aeruginosa isolated from various clinical specimens in Khartoum State, Sudan: a cross sectional study
por: Abdelrahman, Dina N., et al.
Publicado: (2021)

Virtual Screening and Structure-Based Discovery of Indole Acylguanidines as Potent β-secretase (BACE1) Inhibitors
por: Zou, Yiquan, et al.
Publicado: (2013)

Virtual screening of AmpC/β‐lactamase as target for antimicrobial resistance in Pseudomonas aeruginosa
por: Farmer, Rohit, et al.
Publicado: (2010)

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli
por: Lang, Pauline A., et al.
Publicado: (2020)

Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition
por: Wade, Nicola, et al.
Publicado: (2021)

New classes of potent heparanase inhibitors from ligand-based virtual screening
por: Pala, Daniele, et al.
Publicado: (2020)

Association of bla(VIM-2), bla(PDC-35), bla(OXA-10,) bla(OXA-488) and bla(VEB-9) β-Lactamase Genes with Resistance to Ceftazidime–Avibactam and Ceftolozane–Tazobactam in Multidrug-Resistant Pseudomonas aeruginosa
por: Sid Ahmed, Mazen A., et al.
Publicado: (2022)

Biochemical exploration of β-lactamase inhibitors
por: Arer, Varshaa, et al.
Publicado: (2023)

Identification of Potent VEGF Inhibitors for the Clinical Treatment of Glioblastoma, A Virtual Screening Approach
por: Yadav, Mohini, et al.
Publicado: (2019)

Virtual Screening and Biological Activity Evaluation of New Potent Inhibitors Targeting Hexokinase-II
por: Liu, Ruijuan, et al.
Publicado: (2022)

Pharmacokinetics of Non-β-Lactam β-Lactamase Inhibitors
por: Luci, Giacomo, et al.
Publicado: (2021)

Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M β-Lactamases: Biochemical and Structural Analyses
por: Alsenani, Tahani A., et al.
Publicado: (2023)

Discovery of Quercetin and Its Analogs as Potent OXA-48 Beta-Lactamase Inhibitors
por: Zhang, Yuejuan, et al.
Publicado: (2022)

A small molecular inhibitor of LRRK1 identified by homology modeling and virtual screening suppresses osteoclast function, but not osteoclast differentiation, in vitro
por: Si, Mingjue, et al.
Publicado: (2019)

Production of β-Lactamase Inhibitors by Streptomyces Species
por: Viana Marques, Daniela de Araújo, et al.
Publicado: (2018)

Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters
por: Palica, Katarzyna, et al.
Publicado: (2022)

Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening
por: Hegazy, Lamees, et al.
Publicado: (2022)

The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-β-Lactamases Homologs
por: Fonseca, Erica L., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gisv1ndbnst4pavakc6rk1cump