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Roles for transcript leaders in translation and mRNA decay revealed by transcript leader sequencing
Transcript leaders (TLs) can have profound effects on mRNA translation and stability. To map TL boundaries genome-wide, we developed TL-sequencing (TL-seq), a technique combining enzymatic capture of m(7)G-capped mRNA 5′ ends with high-throughput sequencing. TL-seq identified mRNA start sites for th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668365/ https://www.ncbi.nlm.nih.gov/pubmed/23580730 http://dx.doi.org/10.1101/gr.150342.112 |