Mutation analysis of the EGFR gene and downstream signalling pathway in histologic samples of malignant pleural mesothelioma

BACKGROUND: As epidermal growth factor receptor (EGFR) is involved in the pathogenesis of malignant pleural mesotheliomas (MPMs), the anti-EGFR drugs may be effective in treating MPM patients. Mutations of the EGFR gene or its downstream effectors may cause constitutive activation leading to cell pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Mezzapelle, R, Miglio, U, Rena, O, Paganotti, A, Allegrini, S, Antona, J, Molinari, F, Frattini, M, Monga, G, Alabiso, O, Boldorini, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668472/
https://www.ncbi.nlm.nih.gov/pubmed/23558893
http://dx.doi.org/10.1038/bjc.2013.130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668472/
https://www.ncbi.nlm.nih.gov/pubmed/23558893
http://dx.doi.org/10.1038/bjc.2013.130

Ejemplares similares