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Crystal structure of human angiogenin with an engineered loop exhibits conformational flexibility at the functional regions of the molecule()

Human angiogenin (ANG) is an angiogenic molecule and a ribonucleolytic enzyme with significant amino acid sequence identity to pancreatic RNase A, plays a critical role in the establishment and growth of tumours. An association between ANG and cancer has been observed in more than 25 clinical studie...

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Detalles Bibliográficos
Autores principales: Thiyagarajan, Nethaji, Acharya, K. Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668512/
https://www.ncbi.nlm.nih.gov/pubmed/23772376
http://dx.doi.org/10.1016/j.fob.2012.12.003