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Crystal structure of human angiogenin with an engineered loop exhibits conformational flexibility at the functional regions of the molecule()
Human angiogenin (ANG) is an angiogenic molecule and a ribonucleolytic enzyme with significant amino acid sequence identity to pancreatic RNase A, plays a critical role in the establishment and growth of tumours. An association between ANG and cancer has been observed in more than 25 clinical studie...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668512/ https://www.ncbi.nlm.nih.gov/pubmed/23772376 http://dx.doi.org/10.1016/j.fob.2012.12.003 |