Isothermal titration calorimetry with micelles: Thermodynamics of inhibitor binding to carnitine palmitoyltransferase 2 membrane protein()

Carnitine palmitoyl transferase 2 (CPT-2) is a key enzyme in the mitochondrial fatty acid metabolism. The active site is comprised of a Y-shaped tunnel with distinct binding sites for the substrate acylcarnitine and the cofactor CoA. We investigated the thermodynamics of binding of four inhibitors d...

Descripción completa

Detalles Bibliográficos
Autores principales: Perspicace, Samantha, Rufer, Arne C., Thoma, Ralf, Mueller, Francis, Hennig, Michael, Ceccarelli, Simona, Schulz-Gasch, Tanja, Seelig, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668529/
https://www.ncbi.nlm.nih.gov/pubmed/23772395
http://dx.doi.org/10.1016/j.fob.2013.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668529/
https://www.ncbi.nlm.nih.gov/pubmed/23772395
http://dx.doi.org/10.1016/j.fob.2013.04.003

Ejemplares similares