GSK-3β signaling determines autophagy activation in the breast tumor cell line MCF7 and inclusion formation in the non-tumor cell line MCF10A in response to proteasome inhibition

The ubiquitin–proteasome system and the autophagy–lysosome pathway are the two main mechanisms for eukaryotic intracellular protein degradation. Proteasome inhibitors are used for the treatment of some types of cancer, whereas autophagy seems to have a dual role in tumor cell survival and death. How...

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Detalles Bibliográficos
Autores principales: Gavilán, E, Sánchez-Aguayo, I, Daza, P, Ruano, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668630/
https://www.ncbi.nlm.nih.gov/pubmed/23559006
http://dx.doi.org/10.1038/cddis.2013.95

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668630/
https://www.ncbi.nlm.nih.gov/pubmed/23559006
http://dx.doi.org/10.1038/cddis.2013.95

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