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mSWI/SNF (BAF) Complexes Facilitate Decatentation of DNA by Topoisomerase IIα

Recent exon sequencing studies of human tumors have revealed that subunits of mSWI/SNF or BAF complexes are mutated in more than 20% of all human malignancies,(1,2) yet the mechanisms involved in tumor suppression are unclear. BAF chromatin remodeling complexes are polymorphic assemblies that use en...

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Detalles Bibliográficos
Autores principales: Dykhuizen, Emily C., Hargreaves, Diana C., Miller, Erik, Cui, Kairong, Korshunov, Andrey, Kool, Marcel, Pfister, Stefan, Cho, Yoon-Jae, Zhao, Keji, Crabtree, Gerald R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668793/
https://www.ncbi.nlm.nih.gov/pubmed/23698369
http://dx.doi.org/10.1038/nature12146