Determination of Olanzapine and N-desmethyl-olanzapine in Plasma Using a Reversed-Phase HPLC Coupled with Coulochemical Detection: Correlation of Olanzapine or N-desmethyl-olanzapine Concentration with Metabolic Parameters

BACKGROUND: Olanzapine (OLZ) is one of the most prescribed atypical antipsychotic drugs but its use is associated with unfavorable metabolic abnormalities. N-desmethyl-olanzapine (DMO), one of the OLZ metabolites by CYP1A2, has been reported to have a normalizing action on metabolic abnormalities, b...

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Detalles Bibliográficos
Autores principales: Lu, Mong-Liang, Lin, Chia-Hui, Chen, Yi-Chuan, Yang, Huai-Chih, Wu, Tzu-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669135/
https://www.ncbi.nlm.nih.gov/pubmed/23741510
http://dx.doi.org/10.1371/journal.pone.0065719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669135/
https://www.ncbi.nlm.nih.gov/pubmed/23741510
http://dx.doi.org/10.1371/journal.pone.0065719

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