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Endolymphatic Na(+) and K(+) Concentrations during Cochlear Growth and Enlargement in Mice Lacking Slc26a4/pendrin

Slc26a4 (Δ/Δ) mice are deaf, develop an enlarged membranous labyrinth, and thereby largely resemble the human phenotype where mutations of SLC26A4 cause an enlarged vestibular aqueduct and sensorineural hearing loss. The enlargement is likely caused by abnormal ion and fluid transport during the tim...

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Detalles Bibliográficos
Autores principales: Li, Xiangming, Zhou, Fei, Marcus, Daniel C., Wangemann, Philine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669272/
https://www.ncbi.nlm.nih.gov/pubmed/23741519
http://dx.doi.org/10.1371/journal.pone.0065977