Identification of a Human Protein-Derived HIV-1 Fusion Inhibitor Targeting the gp41 Fusion Core Structure

The HIV-1 envelope glycoprotein (Env) gp41 plays a crucial role in the viral fusion process. The peptides derived from the C-terminal heptad repeat (CHR) of gp41 are potent HIV fusion inhibitors. However, the activity of these anti-HIV-1 peptides in vivo may be attenuated by their induction of anti-...

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Detalles Bibliográficos
Autores principales: Chao, Lijun, Lu, Lu, Yang, Hengwen, Zhu, Yun, Li, Yuan, Wang, Qian, Yu, Xiaowen, Jiang, Shibo, Chen, Ying-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669275/
https://www.ncbi.nlm.nih.gov/pubmed/23741527
http://dx.doi.org/10.1371/journal.pone.0066156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669275/
https://www.ncbi.nlm.nih.gov/pubmed/23741527
http://dx.doi.org/10.1371/journal.pone.0066156

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