Dissociations in the Effects of β(2)-Adrenergic Receptor Agonists on cAMP Formation and Superoxide Production in Human Neutrophils: Support for the Concept of Functional Selectivity

In neutrophils, activation of the β(2)-adrenergic receptor (β(2)AR), a G(s)-coupled receptor, inhibits inflammatory responses, which could be therapeutically exploited. The aim of this study was to evaluate the effects of various β(2)AR ligands on adenosine-3′,5′-cyclic monophosphate (cAMP) accumula...

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Detalles Bibliográficos
Autores principales: Brunskole Hummel, Irena, Reinartz, Michael T., Kälble, Solveig, Burhenne, Heike, Schwede, Frank, Buschauer, Armin, Seifert, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669315/
https://www.ncbi.nlm.nih.gov/pubmed/23741338
http://dx.doi.org/10.1371/journal.pone.0064556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669315/
https://www.ncbi.nlm.nih.gov/pubmed/23741338
http://dx.doi.org/10.1371/journal.pone.0064556

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