A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp

30% of epilepsy patients receiving antiepileptic drugs (AEDs) are not fully controlled by therapy. The drug transporter hypothesis for refractory epilepsy proposes that P-gp is over expressed at the epileptic focus with a role of P-gp in extruding AEDs from the brain. However, there is controversy r...

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Detalles Bibliográficos
Autores principales: Dickens, David, Yusof, Siti R., Abbott, N. Joan, Weksler, Babette, Romero, Ignacio A., Couraud, Pierre-Olivier, Alfirevic, Ana, Pirmohamed, Munir, Owen, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669347/
https://www.ncbi.nlm.nih.gov/pubmed/23741405
http://dx.doi.org/10.1371/journal.pone.0064854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669347/
https://www.ncbi.nlm.nih.gov/pubmed/23741405
http://dx.doi.org/10.1371/journal.pone.0064854

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