Alternative Computational Protocols for Supercharging Protein Surfaces for Reversible Unfolding and Retention of Stability

Reengineering protein surfaces to exhibit high net charge, referred to as “supercharging”, can improve reversibility of unfolding by preventing aggregation of partially unfolded states. Incorporation of charged side chains should be optimized while considering structural and energetic consequences,...

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Detalles Bibliográficos
Autores principales: Der, Bryan S., Kluwe, Christien, Miklos, Aleksandr E., Jacak, Ron, Lyskov, Sergey, Gray, Jeffrey J., Georgiou, George, Ellington, Andrew D., Kuhlman, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669367/
https://www.ncbi.nlm.nih.gov/pubmed/23741319
http://dx.doi.org/10.1371/journal.pone.0064363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669367/
https://www.ncbi.nlm.nih.gov/pubmed/23741319
http://dx.doi.org/10.1371/journal.pone.0064363

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