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Effects of DNMT1 and HDAC Inhibitors on Gene-Specific Methylation Reprogramming during Porcine Somatic Cell Nuclear Transfer

Somatic cell nuclear transfer (SCNT) in mammalian cloning currently remains inefficient. Incomplete or erroneous epigenetic reprogramming of specialized donor somatic nuclear and resulting aberrant gene expression during development of cloned embryos is commonly believed as the main reason that caus...

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Detalles Bibliográficos
Autores principales: Xu, Weihua, Li, Zicong, Yu, Bo, He, Xiaoyan, Shi, Junsong, Zhou, Rong, Liu, Dewu, Wu, Zhenfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669391/
https://www.ncbi.nlm.nih.gov/pubmed/23741375
http://dx.doi.org/10.1371/journal.pone.0064705