Does Naloxone Reinstate Secondary Hyperalgesia in Humans after Resolution of a Burn Injury? A Placebo-Controlled, Double-Blind, Randomized, Cross-Over Study

INTRODUCTION: Development of secondary hyperalgesia following a cutaneous injury is a centrally mediated, robust phenomenon. The pathophysiological role of endogenous opioid signalling to the development of hyperalgesia is unclear. Recent animal studies, carried out after the resolution of inflammat...

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Detalles Bibliográficos
Autores principales: Pereira, Manuel P., Werner, Mads U., Ringsted, Thomas K., Rowbotham, Michael C., Taylor, Bradley K., Dahl, Joergen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669421/
https://www.ncbi.nlm.nih.gov/pubmed/23741350
http://dx.doi.org/10.1371/journal.pone.0064608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669421/
https://www.ncbi.nlm.nih.gov/pubmed/23741350
http://dx.doi.org/10.1371/journal.pone.0064608

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