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Ubiquitin-mediated regulation of JAK-STAT signaling in embryonic stem cells

LIF activates several intracellular signaling pathways including JAK-STAT, PI3K/AKT and MAPK pathways. LIF is an important cytokine for maintenance of pluripotency and self-renewal of mouse ES cells. The JAK-STAT signal plays a key role in maintenance of the pluripotency of ESCs. Recent evidence sho...

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Detalles Bibliográficos
Autor principal: Hatakeyama, Shigetsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670240/
https://www.ncbi.nlm.nih.gov/pubmed/24058766
http://dx.doi.org/10.4161/jkst.21560