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A rapid conformational rearrangement of STAT1 dimers is required for termination rather than for amplification of interferon-γ signaling
Sequence-specific binding of STAT1 (signal transducer and activator of transcription 1) transcription factor to palindromic promoter elements, termed γ-activated sites (GAS), and an extended spatial reorientation between two dimer configurations are key events in the interferon signaling pathway. Al...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670273/ https://www.ncbi.nlm.nih.gov/pubmed/24058797 http://dx.doi.org/10.4161/jkst.23576 |