Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222

BACKGROUND: Most of the heritable risk of glioma is presently unaccounted for by mutations in known genes. In addition to rare inactivating germline mutations in TP53 causing glioma in the context of the Li-Fraumeni syndrome, polymorphic variation in TP53 may also contribute to the risk of developin...

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Detalles Bibliográficos
Autores principales: Enciso-Mora, V, Hosking, F J, Di Stefano, A L, Zelenika, D, Shete, S, Broderick, P, Idbaih, A, Delattre, J-Y, Hoang-Xuan, K, Marie, Y, Labussière, M, Alentorn, A, Ciccarino, P, Rossetto, M, Armstrong, G, Liu, Y, Gousias, K, Schramm, J, Lau, C, Hepworth, S J, Schoemaker, M, Strauch, K, Müller-Nurasyid, M, Schreiber, S, Franke, A, Moebus, S, Eisele, L, Swerdlow, A, Simon, M, Bondy, M, Lathrop, M, Sanson, M, Houlston, R S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670481/
https://www.ncbi.nlm.nih.gov/pubmed/23571737
http://dx.doi.org/10.1038/bjc.2013.155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670481/
https://www.ncbi.nlm.nih.gov/pubmed/23571737
http://dx.doi.org/10.1038/bjc.2013.155

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