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Tumor Necrosis Factor-α Promotes Cholestasis-Induced Liver Fibrosis in the Mouse through Tissue Inhibitor of Metalloproteinase-1 Production in Hepatic Stellate Cells

Tumor necrosis factor (TNF)-α, which is a mediator of hepatotoxicity, has been implicated in liver fibrosis. However, the roles of TNF-α on hepatic stellate cell (HSC) activation and liver fibrosis are complicated and remain controversial. To explore this issue, the role of TNF-α in cholestasis-indu...

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Detalles Bibliográficos
Autores principales: Osawa, Yosuke, Hoshi, Masato, Yasuda, Ichiro, Saibara, Toshiji, Moriwaki, Hisataka, Kozawa, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670853/
https://www.ncbi.nlm.nih.gov/pubmed/23755201
http://dx.doi.org/10.1371/journal.pone.0065251