Lung Myofibroblasts Are Characterized by Down-Regulated Cyclooxygenase-2 and Its Main Metabolite, Prostaglandin E2

BACKGROUND: Prostaglandin E2 (PGE(2)), the main metabolite of cyclooxygenase (COX), is a well-known anti-fibrotic agent. Moreover, myofibroblasts expressing α-smooth muscle actin (α-SMA), fibroblast expansion and epithelial-mesenchymal transition (EMT) are critical to the pathogenesis of idiopathic...

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Detalles Bibliográficos
Autores principales: Gabasa, Marta, Royo, Dolores, Molina-Molina, Maria, Roca-Ferrer, Jordi, Pujols, Laura, Picado, Cesar, Xaubet, Antoni, Pereda, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670886/
https://www.ncbi.nlm.nih.gov/pubmed/23755232
http://dx.doi.org/10.1371/journal.pone.0065445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670886/
https://www.ncbi.nlm.nih.gov/pubmed/23755232
http://dx.doi.org/10.1371/journal.pone.0065445

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