Tacrolimus (FK506) Prevents Early Stages of Ethanol Induced Hepatic Fibrosis by Targeting LARP6 Dependent Mechanism of Collagen Synthesis

Tacrolimus (FK506) is a widely used immunosuppressive drug. Its effects on hepatic fibrosis have been controversial and attributed to immunosuppression. We show that in vitro FK506, inhibited synthesis of type I collagen polypeptides, without affecting expression of collagen mRNAs. In vivo, administ...

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Detalles Bibliográficos
Autores principales: Manojlovic, Zarko, Blackmon, John, Stefanovic, Branko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670911/
https://www.ncbi.nlm.nih.gov/pubmed/23755290
http://dx.doi.org/10.1371/journal.pone.0065897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670911/
https://www.ncbi.nlm.nih.gov/pubmed/23755290
http://dx.doi.org/10.1371/journal.pone.0065897

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