A Phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteers

ABSTRACT: This Phase I study aimed to assess the potential drug-drug interactions (pharmacokinetic [PK] and safety profile) of Δ9-tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray (Sativex (®), nabiximols) in combination with cytochrome P450 (CYP450) inducer (rifampicin) or inhibitors (k...

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Detalles Bibliográficos
Autores principales: Stott, Colin, White, Linda, Wright, Stephen, Wilbraham, Darren, Guy, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing AG 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671111/
https://www.ncbi.nlm.nih.gov/pubmed/23750331
http://dx.doi.org/10.1186/2193-1801-2-236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671111/
https://www.ncbi.nlm.nih.gov/pubmed/23750331
http://dx.doi.org/10.1186/2193-1801-2-236

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