Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase

BACKGROUND: GSK3β is involved in a wide range of physiological functions, and is presumed to act in the pathogenesis of neurological diseases, from bipolar disorder to Alzheimer’s disease (AD). In contrast, the GSK3α isozyme remained largely ignored with respect to both aspects. RESULTS: We generate...

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Detalles Bibliográficos
Autores principales: Maurin, Hervé, Lechat, Benoit, Dewachter, Ilse, Ris, Laurence, Louis, Justin V, Borghgraef, Peter, Devijver, Herman, Jaworski, Tomasz, Van Leuven, Fred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671145/
https://www.ncbi.nlm.nih.gov/pubmed/23705847
http://dx.doi.org/10.1186/1756-6606-6-27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671145/
https://www.ncbi.nlm.nih.gov/pubmed/23705847
http://dx.doi.org/10.1186/1756-6606-6-27

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