Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

The majority of human cancers harbour mutations promoting activation of the Akt protein kinase, and Akt inhibitors are being evaluated in clinical trials. An important question concerns the understanding of the innate mechanisms that confer resistance of tumour cells to Akt inhibitors. SGK (serum- a...

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Detalles Bibliográficos
Autores principales: Sommer, Eeva M., Dry, Hannah, Cross, Darren, Guichard, Sylvie, Davies, Barry R., Alessi, Dario R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671793/
https://www.ncbi.nlm.nih.gov/pubmed/23581296
http://dx.doi.org/10.1042/BJ20130342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671793/
https://www.ncbi.nlm.nih.gov/pubmed/23581296
http://dx.doi.org/10.1042/BJ20130342

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