Lysyl Oxidase Is Downregulated by the EWS/FLI1 Oncoprotein and Its Propeptide Domain Displays Tumor Supressor Activities in Ewing Sarcoma Cells

Ewing sarcoma is the second most common bone malignancy in children and young adults. It is driven by oncogenic fusion proteins (i.e. EWS/FLI1) acting as aberrant transcription factors that upregulate and downregulate target genes, leading to cellular transformation. Thus, identificating these targe...

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Detalles Bibliográficos
Autores principales: Agra, Noelia, Cidre, Florencia, García-García, Laura, de la Parra, Juan, Alonso, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672102/
https://www.ncbi.nlm.nih.gov/pubmed/23750284
http://dx.doi.org/10.1371/journal.pone.0066281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672102/
https://www.ncbi.nlm.nih.gov/pubmed/23750284
http://dx.doi.org/10.1371/journal.pone.0066281

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