Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy

Amino acids, leucine in particular, are known to inhibit autophagy, at least in part by their ability to stimulate MTOR-mediated signaling. Evidence is presented showing that glutamate dehydrogenase, the central enzyme in amino acid catabolism, contributes to leucine sensing in the regulation of aut...

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Detalles Bibliográficos
Autores principales: Lorin, Séverine, Tol, Marc J., Bauvy, Chantal, Strijland, Anneke, Poüs, Christian, Verhoeven, Arthur J., Codogno, Patrice, Meijer, Alfred J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Basic Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672295/
https://www.ncbi.nlm.nih.gov/pubmed/23575388
http://dx.doi.org/10.4161/auto.24083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672295/
https://www.ncbi.nlm.nih.gov/pubmed/23575388
http://dx.doi.org/10.4161/auto.24083

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