Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy

Amino acids, leucine in particular, are known to inhibit autophagy, at least in part by their ability to stimulate MTOR-mediated signaling. Evidence is presented showing that glutamate dehydrogenase, the central enzyme in amino acid catabolism, contributes to leucine sensing in the regulation of aut...

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Autores principales: Lorin, Séverine, Tol, Marc J., Bauvy, Chantal, Strijland, Anneke, Poüs, Christian, Verhoeven, Arthur J., Codogno, Patrice, Meijer, Alfred J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Basic Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672295/
https://www.ncbi.nlm.nih.gov/pubmed/23575388
http://dx.doi.org/10.4161/auto.24083
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author Lorin, Séverine
Tol, Marc J.
Bauvy, Chantal
Strijland, Anneke
Poüs, Christian
Verhoeven, Arthur J.
Codogno, Patrice
Meijer, Alfred J.
author_facet Lorin, Séverine
Tol, Marc J.
Bauvy, Chantal
Strijland, Anneke
Poüs, Christian
Verhoeven, Arthur J.
Codogno, Patrice
Meijer, Alfred J.
author_sort Lorin, Séverine
collection PubMed
description Amino acids, leucine in particular, are known to inhibit autophagy, at least in part by their ability to stimulate MTOR-mediated signaling. Evidence is presented showing that glutamate dehydrogenase, the central enzyme in amino acid catabolism, contributes to leucine sensing in the regulation of autophagy. The data suggest a dual mechanism by which glutamate dehydrogenase activity modulates autophagy, i.e., by activating MTORC1 and by limiting the formation of reactive oxygen species.
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spelling pubmed-36722952013-06-27 Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy Lorin, Séverine Tol, Marc J. Bauvy, Chantal Strijland, Anneke Poüs, Christian Verhoeven, Arthur J. Codogno, Patrice Meijer, Alfred J. Autophagy Basic Brief Report Amino acids, leucine in particular, are known to inhibit autophagy, at least in part by their ability to stimulate MTOR-mediated signaling. Evidence is presented showing that glutamate dehydrogenase, the central enzyme in amino acid catabolism, contributes to leucine sensing in the regulation of autophagy. The data suggest a dual mechanism by which glutamate dehydrogenase activity modulates autophagy, i.e., by activating MTORC1 and by limiting the formation of reactive oxygen species. Landes Bioscience 2013-06-01 2013-04-10 /pmc/articles/PMC3672295/ /pubmed/23575388 http://dx.doi.org/10.4161/auto.24083 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Basic Brief Report
Lorin, Séverine
Tol, Marc J.
Bauvy, Chantal
Strijland, Anneke
Poüs, Christian
Verhoeven, Arthur J.
Codogno, Patrice
Meijer, Alfred J.
Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
title Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
title_full Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
title_fullStr Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
title_full_unstemmed Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
title_short Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
title_sort glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
topic Basic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672295/
https://www.ncbi.nlm.nih.gov/pubmed/23575388
http://dx.doi.org/10.4161/auto.24083
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