Spread of neuronal degeneration in a dopaminergic, Lrrk-G2019S model of Parkinson disease

Flies expressing the most common Parkinson disease (PD)-related mutation, LRRK2-G2019S, in their dopaminergic neurons show loss of visual function and degeneration of the retina, including mitochondrial abnormalities, apoptosis and autophagy. Since the photoreceptors that degenerate are not dopamine...

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Detalles Bibliográficos
Autores principales: Hindle, Samantha J., Elliott, Christopher J.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Autophagic Punctum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672307/
https://www.ncbi.nlm.nih.gov/pubmed/23529190
http://dx.doi.org/10.4161/auto.24397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672307/
https://www.ncbi.nlm.nih.gov/pubmed/23529190
http://dx.doi.org/10.4161/auto.24397

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