Netrin-1 regulates the inflammatory response of neutrophils and macrophages, and suppresses ischemic acute kidney injury by inhibiting COX-2 mediated PGE2 production

Netrin-1 regulates inflammation but the mechanism by which this occurs is unknown. Here we explore the role of netrin-1 in regulating the production of the prostanoid metabolite PGE2 from neutrophils in in vitro and in vivo disease models. Ischemia reperfusion in wild-type and RAG-1 knockout mice in...

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Detalles Bibliográficos
Autores principales: Ranganathan, Punithavathi Vilapakkam, Jayakumar, Calpurnia, Mohamed, Riyaz, Dong, Zheng, Ramesh, Ganesan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672333/
https://www.ncbi.nlm.nih.gov/pubmed/23447066
http://dx.doi.org/10.1038/ki.2012.423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672333/
https://www.ncbi.nlm.nih.gov/pubmed/23447066
http://dx.doi.org/10.1038/ki.2012.423

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