Cargando…

CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

INTRODUCTION: Osteoarthritis (OA) is the most common degenerative joint disease that is involved in the degradation of articular cartilage. The exact etiology of OA is not completely understood. CCN4 is related to up-regulation in the cartilage of patients with osteoarthritis. Previous studies have...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hou, Chun-Han, Tang, Chih-Hsin, Hsu, Chin-Jung, Hou, Sheng-Mon, Liu, Ju-Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672729/ https://www.ncbi.nlm.nih.gov/pubmed/23343403 http://dx.doi.org/10.1186/ar4151

Ejemplares similares

Thrombospondin 2 Promotes IL-6 Production in Osteoarthritis Synovial Fibroblasts via the PI3K/AKT/NF-κB Pathway
por: Hou, Chun-Han, et al.
Publicado: (2021)

CCN1 Promotes Inflammation by Inducing IL-6 Production via α6β1/PI3K/Akt/NF-κB Pathway in Autoimmune Hepatitis
por: Jiang, Renquan, et al.
Publicado: (2022)

IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways
por: Hwang, Sue-Yun, et al.
Publicado: (2004)

CCN3 Facilitates Runx2 and Osterix Expression by Inhibiting miR-608 through PI3K/Akt Signaling in Osteoblasts
por: Chen, Po-Chun, et al.
Publicado: (2019)

Si-Wu-tang extract stimulates bone formation through PI3K/Akt/NF-κB signaling pathways in osteoblasts
por: Wu, Chi-Ming, et al.
Publicado: (2013)

E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts
por: Wang, Shiguan, et al.
Publicado: (2018)

S1P promotes IL-6 expression in osteoblasts through the PI3K, MEK/ERK and NF-κB signaling pathways
por: Hu, Sung-Lin, et al.
Publicado: (2020)

Apelin enhances IL-1β expression in human synovial fibroblasts by inhibiting miR-144-3p through the PI3K and ERK pathways
por: Chang, Ting-Kuo, et al.
Publicado: (2020)

CTGF Increases IL-6 Expression in Human Synovial Fibroblasts through Integrin-Dependent Signaling Pathway
por: Liu, Shan-Chi, et al.
Publicado: (2012)

Correction: CTGF Increases IL-6 Expression in Human Synovial Fibroblasts through Integrin-Dependent Signaling Pathway
por: Liu, Shan-Chi, et al.
Publicado: (2015)

Antcin K Inhibits TNF-α, IL-1β and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis
por: Achudhan, David, et al.
Publicado: (2021)

Antioxidant glutathione inhibits inflammation in synovial fibroblasts via PTEN/PI3K/AKT pathway: An in vitro study
por: Ting Hao, Wen, et al.
Publicado: (2021)

NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway
por: Huang, Xiaojian, et al.
Publicado: (2019)

Nesfatin-1 facilitates IL-1β production in osteoarthritis synovial fibroblasts by suppressing miR-204-5p synthesis through the AP-1 and NF-κB pathways
por: Lee, Kun-Tsan, et al.
Publicado: (2021)

Synovial fibroblast‐targeting liposomes encapsulating an NF‐κB‐blocking peptide ameliorates zymosan‐induced synovial inflammation
por: You, Changcheng, et al.
Publicado: (2018)

Phenethyl Isothiocyanate Suppresses the Proinflammatory Cytokines in Human Glioblastoma Cells through the PI3K/Akt/NF-κB Signaling Pathway In Vitro
por: Hsu, Sheng-Yao, et al.
Publicado: (2022)

microRNA-mediated GAS1 downregulation promotes the proliferation of synovial fibroblasts by PI3K-Akt signaling in osteoarthritis
por: Dong, Chuan, et al.
Publicado: (2019)

Baicalein Induces Apoptosis of Rheumatoid Arthritis Synovial Fibroblasts through Inactivation of the PI3K/Akt/mTOR Pathway
por: Zhang, Xue, et al.
Publicado: (2022)

Cell type-specific regulation of CCN2 protein expression by PI3K–AKT–FoxO signaling
por: Samarin, Jana, et al.
Publicado: (2009)

CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy
por: DI, YU, et al.
Publicado: (2015)

Targeting the PI3K/AKT/mTOR/NFκB Axis in Ovarian Cancer
por: Ghoneum, Alia, et al.
Publicado: (2020)

Leptin Induces IL-6 Expression through OBRl Receptor Signaling Pathway in Human Synovial Fibroblasts
por: Yang, Wei-Hung, et al.
Publicado: (2013)

Cigarette Smoke Extract Stimulates MMP-2 Production in Nasal Fibroblasts via ROS/PI3K, Akt, and NF-κB Signaling Pathways
por: Park, Joo-Hoo, et al.
Publicado: (2020)

Activation of synovial fibroblasts by laminin-1 and transforming growth factor beta induces expression of stromelysins independently of TNFα, IL-1β or NF-κB
por: Warstat, Katrin, et al.
Publicado: (2007)

Isorhamnetin Induces Melanoma Cell Apoptosis via the PI3K/Akt and NF-κB Pathways
por: Duan, Ran, et al.
Publicado: (2020)

Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes
por: Shah, Ankit, et al.
Publicado: (2012)

The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt–VEGF signaling pathway
por: Di, Yu, et al.
Publicado: (2015)

IL-33 regulates TNF-α dependent effects in synovial fibroblasts
por: KUNISCH, ELKE, et al.
Publicado: (2012)

Foxtail Millet Improves Blood Glucose Metabolism in Diabetic Rats through PI3K/AKT and NF-κB Signaling Pathways Mediated by Gut Microbiota
por: Ren, Xin, et al.
Publicado: (2021)

Complex Systems Biology Approach in Connecting PI3K-Akt and NF-κB Pathways in Prostate Cancer
por: Shankar, Eswar, et al.
Publicado: (2019)

PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics
por: Ghoneum, Alia, et al.
Publicado: (2019)

PLCA8 suppresses breast cancer apoptosis by activating the PI3k/AKT/NF‐κB pathway
por: Mao, Misha, et al.
Publicado: (2019)

The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts
por: Todorovicç, Viktor, et al.
Publicado: (2005)

Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression
por: Bharadwaj, Uddalak, et al.
Publicado: (2011)

D-Lactate Increases Cytokine Production in Bovine Fibroblast-Like Synoviocytes via MCT1 Uptake and the MAPK, PI3K/Akt, and NFκB Pathways
por: Manosalva, Carolina, et al.
Publicado: (2020)

Zuo Jin Wan reverses P-gp-mediated drug-resistance by inhibiting activation of the PI3K/Akt/NF-κB pathway
por: Sui, Hua, et al.
Publicado: (2014)

AKT regulates TNF-alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts
por: Mountz, JD, et al.
Publicado: (2001)

Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-κB-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways
por: Zhang, Weizhe, et al.
Publicado: (2018)

IL-17 Facilitates VCAM-1 Production and Monocyte Adhesion in Osteoarthritis Synovial Fibroblasts by Suppressing miR-5701 Synthesis
por: Wu, Tsung-Ju, et al.
Publicado: (2022)

Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells
por: Li, Fangqi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_s767519lvpgdaohidn81i74tqb