The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer

INTRODUCTION: Loss of the retinoblastoma protein tumor suppressor gene (RB) coding for a nuclear phosphoprotein that regulates the cell cycle is found in many human cancers and probably leads to disruption of the p16-cyclin D1-CDK4/6-RB pathway. Cyclin D1 is known to activate CDK4, which then phosph...

Descripción completa

Detalles Bibliográficos
Autores principales: Peurala, Emmi, Koivunen, Peppi, Haapasaari, Kirsi-Maria, Bloigu, Risto, Jukkola-Vuorinen, Arja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672746/
https://www.ncbi.nlm.nih.gov/pubmed/23336272
http://dx.doi.org/10.1186/bcr3376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672746/
https://www.ncbi.nlm.nih.gov/pubmed/23336272
http://dx.doi.org/10.1186/bcr3376

Ejemplares similares