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The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer

INTRODUCTION: Loss of the retinoblastoma protein tumor suppressor gene (RB) coding for a nuclear phosphoprotein that regulates the cell cycle is found in many human cancers and probably leads to disruption of the p16-cyclin D1-CDK4/6-RB pathway. Cyclin D1 is known to activate CDK4, which then phosph...

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Detalles Bibliográficos
Autores principales:	Peurala, Emmi, Koivunen, Peppi, Haapasaari, Kirsi-Maria, Bloigu, Risto, Jukkola-Vuorinen, Arja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672746/ https://www.ncbi.nlm.nih.gov/pubmed/23336272 http://dx.doi.org/10.1186/bcr3376

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