Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes

INTRODUCTION: This study investigated whether the calcineurin inhibitor, tacrolimus, suppresses receptor activator of NF-κB ligand (RANKL) expression in fibroblast-like synoviocytes (FLS) through regulation of IL-6/Janus activated kinase (JAK2)/signal transducer and activator of transcription-3 (STA...

Descripción completa

Detalles Bibliográficos
Autores principales: Choe, Jung-Yoon, Park, Ki-Yeun, Park, Sung-Hoon, Lee, Sang-Il, Kim, Seong-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672788/
https://www.ncbi.nlm.nih.gov/pubmed/23406906
http://dx.doi.org/10.1186/ar4162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672788/
https://www.ncbi.nlm.nih.gov/pubmed/23406906
http://dx.doi.org/10.1186/ar4162

Ejemplares similares