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Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes

INTRODUCTION: This study investigated whether the calcineurin inhibitor, tacrolimus, suppresses receptor activator of NF-κB ligand (RANKL) expression in fibroblast-like synoviocytes (FLS) through regulation of IL-6/Janus activated kinase (JAK2)/signal transducer and activator of transcription-3 (STA...

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Detalles Bibliográficos
Autores principales:	Choe, Jung-Yoon, Park, Ki-Yeun, Park, Sung-Hoon, Lee, Sang-Il, Kim, Seong-Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672788/ https://www.ncbi.nlm.nih.gov/pubmed/23406906 http://dx.doi.org/10.1186/ar4162

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